Articles & Research
Stay up to date on the latest VEXAS research
VEXAS Foundation website provides timely access to the latest scientific advances. Articles are continually updated with the latest developments in research and treatment options.
General articles
VEXAS June 2026 Newsletter https://mailchi.mp/vexas/june-2026-vexas-foundation-newsletter
VEXAS September 2025 Newsletter https://mailchi.mp/vexas/september-2025-newsletter
VEXAS June 2025 Newsletter https://mailchi.mp/vexas/vexas-foundation-june-2025-newsletter
VEXAS March 2025 Newsletter: https://mailchi.mp/vexas/march-2025-vexas-newsletter
VEXAS December 2024 Newsletter: https://mailchi.mp/vexas/vexas-december-newsletter
VEXAS September 2024 Newsletter: https://mailchi.mp/vexas/vexas-foundation-september-newsletter
VEXAS July 2024 Newsletter: https://mailchi.mp/vexas/vexas-news-letter
A very good overview of VEXAS Syndrome, including nine studies listed in Table One VEXAS Syndrome—Review – PMC (nih.gov)
Holly Carpenter opens up about nasty online trolls amid her father’s cancer diagnosis. 3/3/24 www.irishmirror.ie/showbiz/holly-carpenter-opens-up-nasty-32263185
Who should be tested for VEXAS syndrome? 2/14/24 www.diacarta.com/who-should-be-tested-for-vexas-syndrome
VEXAS syndrome: A review of cutaneous findings and treatments in an emerging autoinflammatory disease. 3/12/24 www.onlinelibrary.wiley.com/doi/10.1111/exd.15050
Recently identified inflammatory disease VEXAS syndrome may be more common than thought. 1/24/23 www.cnn.com/2023/01/24/health/vexas-syndrome-prevalence-study-wellness/index.html
A Little-Known Inflammatory Disease Is Hiding in Plain Sight 2/14/23 www.wired.com/story/vexas-new-disease-genetics/
Research articles
- Efficacy and safety of targeted therapies in VEXAS
syndrome: retrospective study from the FRENVEX - VEXAS Patient Experience Survey https://vexas.org/wp-content/uploads/2024/12/The-Patient-Experience-Final.pdf
- Shared and distinct mechanisms of UBA1 inactivation across different diseases | The EMBO Journal (embopress.org) as reported by David Beck Lab – NYU Feb 2024
- Efficacy and safety of targeted therapies in VEXAS syndrome – ARD 2024
- Serious infections in patients with VEXAS syndrome – French VEXAS registry – ARD 2023
- Skin manifestations of VEXAS Syndrome June 2024
- Somatic Mutations in UBA1 and Severe Adult Onset Autoinflammatory Disease” by Beck DB et al New England Journal of Medicine
- “Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis” by Ferrada MA et al Blood 2022
- “Further characterization of clinical and laboratory features in VEXAS syndrome: large-scale analysis of a multicentre case series of 116 patients” by Georgin-Lavialle S et al British Journal of Dermatology 2021
- “Estimated Prevalence and Clinical Manifestation of UBA1 variants Associated with VEXAS Syndrome in a Clinical Population” by Beck DB et al Journal of the American Medical Association 2023
- “Ruxolitinib is more effective than other JAK inhibitors to treat VEXAS syndrome: a restrospective multicenter study” by Heiblig et al Blood 2022
- “Sensitivity to targeted UBA1 inhibition in a myeloid cell line model of VEXAS syndrome” Chiaramida A et al Blood Advances 2023
- “VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation” by Kosmider O et al. Nature Communications 2024
- “Allogeneic Hematopoieitc Cell Transplantation for VEXAS Syndrome: Results of a Multicenter Study of the EBMT” by by Gurnari C et al. Blood Advances 2024
- “Early Activation of Inflammatory Pathways in UBA1-mutated hematopoietic stem and progenitor cells in VEXAS” by Wu Z Cell Reports Medicine 2023Skin Manifestations of VEXAS SyndromeSkin Manifestations of VEXAS Syndrome
The material contained in these articles is provided for general information and educational purposes only. Only your healthcare professional can address concerns and questions you may have about VEXAS syndrome.
General
Articles
- https://www.cnn.com/2023/01/24/health/vexas-syndrome-prevalence-study-wellness/index.html
- https://www.wired.com/story/vexas-new-disease-genetics/
- https://www.washingtonpost.com/wellness/2023/09/09/fevers-swelling-breathlessness-medical-mystery/
- https://www.washingtonpost.com/dc-md-va/2024/02/03/cia-analyst-rare-disease-vexas/
- https://www.nbcnews.com/health/health-news/vexas-syndrome-scientists-discover-rare-deadly-inflammatory-disorder-men-n1244912
- https://www.medscape.com/viewarticle/985324#:~:text=The%20clinicobiological%20presentation%20of%20VEXAS,by%20the%20sequencing%20of%20UBA1.
- https://www.mdedge.com/rheumatology/article/260770/lupus-connective-tissue-diseases/vexas-syndrome-more-common-variable-and
- https://www.mdedge.com/internalmedicine/article/238315/lupus-connective-tissue-diseases/vexas-novel-rheumatologic/page/0/2
- https://jhm.qa00.mdedge.com/dermatology/article/238910/medical-dermatology
Research
Articles
- Somatic Mutations in UBA1 and Severe Adult Onset Autoinflammatory Disease” by Beck DB et al New England Journal of Medicine
- “Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis” by Ferrada MA et al Blood 2022
- “Further characterization of clinical and laboratory features in VEXAS syndrome: large-scale analysis of a multicentre case series of 116 patients” by Georgin-Lavialle S et al British Journal of Dermatology 2021
- “Estimated Prevalence and Clinical Manifestation of UBA1 variants Associated with VEXAS Syndrome in a Clinical Population” by Beck DB et al Journal of the American Medical Association 2023
- “Ruxolitinib is more effective than other JAK inhibitors to treat VEXAS syndrome: a restrospective multicenter study” by Heiblig et al Blood 2022
- “Sensitivity to targeted UBA1 inhibition in a myeloid cell line model of VEXAS syndrome” Chiaramida A et al Blood Advances 2023
- “VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation” by Kosmider O et al. Nature Communications 2024
- “Allogeneic Hematopoieitc Cell Transplantation for VEXAS Syndrome: Results of a Multicenter Study of the EBMT” by by Gurnari C et al. Blood Advances 2024
- “Early Activation of Inflammatory Pathways in UBA1-mutated hematopoietic stem and progenitor cells in VEXAS” by Wu Z Cell Reports Medicine 2023
Clinical Trials
and Surveys
- Link 1
- Link 2
- Link 3
- Link 4
- Link 5